| Rank | Teams | Points | Played | Won | Drawn | Lost | For | Against | Goal difference |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
 Ñublense |
50 | 28 | 15 | 5 | 8 | 51 | 33 | 18 |
| 2 |
 Unión San Felipe |
46 | 28 | 12 | 10 | 6 | 37 | 25 | 12 |
| 3 |
 Rangers |
45 | 28 | 12 | 9 | 7 | 43 | 39 | 4 |
| 4 |
 Deportes Puerto Montt |
42 | 28 | 11 | 9 | 8 | 36 | 28 | 8 |
| 5 |
 Deportes Melipilla |
42 | 28 | 11 | 9 | 8 | 30 | 23 | 7 |
| 6 |
 Deportes Temuco |
41 | 28 | 11 | 8 | 9 | 35 | 34 | 1 |
| 7 |
 San Marcos de Arica |
41 | 28 | 12 | 5 | 11 | 27 | 29 | -2 |
| 8 |
 Magallanes |
40 | 28 | 9 | 13 | 6 | 31 | 25 | 6 |
| 9 |
 Deportes Copiapó |
39 | 28 | 10 | 9 | 9 | 48 | 46 | 2 |
| 10 |
 Cobreloa |
36 | 28 | 9 | 9 | 10 | 37 | 33 | 4 |
| 11 |
 San Luis de Quillota |
33 | 28 | 8 | 9 | 11 | 31 | 35 | -4 |
| 12 |
 Santiago Morning |
31 | 28 | 7 | 10 | 11 | 29 | 39 | -10 |
| 13 |
 Barnechea |
30 | 28 | 7 | 9 | 12 | 39 | 45 | -6 |
| 14 |
 Deportes Valdivia |
28 | 28 | 6 | 10 | 12 | 34 | 48 | -14 |
| 15 |
 Deportes Santa Cruz |
22 | 28 | 6 | 4 | 18 | 28 | 54 | -26 |
Asciende a Primera División 2021
Juega con ganador de Liguilla
Juega Liguilla
Juega Liguilla
Juega Liguilla
Juega Liguilla
Desciende a Segunda División